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Model-based approach
STEP 1: NTCP model
Multivariable NTCP-models
STEP 2: Individual dose comparison
Dose reduction (
Dose
): relevant DVH parameters?
STEP 3: Estimate NTCP reduction (ΔNTCP)
Translate
Dose
to
NTCP
STEP 4: Validation
External validation NTCP-model with new technology
Langendijk
, et al
. Radiother Oncol 2013;
Courtesy of Hans Langendijk, UMC Groningen
Selection
Validation