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p16 – a promising biomarker in Anal Cancer
p16 – ink4a
Chromosome 9p21
Inhibits entry into S phase of the cell cycle
Binds CDK4/6 inhibiting formation of the cyclin-CDK4/6
complex
HPV E7 protein binds Rb releasing E2F transcription factor
leading to increased p16 expression
p16 overexpression in anal cancer is a useful
surrogate marker of high risk HPV infection !!!