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Biomarkers in anal Carcinoma – Much Ado About
Nothing
•
BCL – 2 : 3 studies 2003 – 2009 ( n = 21 – 98 )
immunohistochemistry in all 3 studies
BCL 2 expressed in 24 – 58 % of cancers
associated with reduced local control and DFS in one study ; no prognostic significance in the
other two
•
Ki67 : 4 studies 1998 – 2009 ( n = 31 – 62 )
Immunohistochemistry ( MIB1 ) used in all studies
No prognostic significance in 2 out of 4 studies ; elevated Ki67 associated with longer DFS in
one study and improved colectomy free survival in a second study.
Others : VEGF - no prognostic significance
MVD - no prognostic significance
PCNA - no prognostic significance
Cyclins - no prognostic significance in 3 out of 4 studies
( Lampejo et al 2010 )