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Biomarkers in Anal Carcinoma – Much Ado About Nothing
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p53 : 8 studies 1996 – 2009 ( n = 14 – 214 )
immunohistochemistry used in all studies
34% – 100 % cancers positive ( 34-60% in 6/8 studies )
All cancers treated with CRT
No prognostic significance in 6/8 series
; reduced DFS in 2/8
•
p21 : 3 studies 2001 – 2006 ( n = 94 – 215 )
immunohistochemistry used in all studies
65 % – 71 % cancers showed positive staining
absent expression associated with reduced OS in one study and a trend towards
reduced DFS in the other two
; significant association with loco-regional failure in one
out of three.
EGFR : 3 studies 2005 – 2009 ( n = 21 – 38 )
immunohistochemistry used in all 3 series
EGFR expression seen in 55 % – 100 % of cancers
NO prognostic significance found
( Lampejo et al 2010 )