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Radiation Response

HPV(+) Cells

Modulation of AKT

Activation

Increased

Apoptosis

Impaired DNA-

DSB Repair

Increased DNA-

Nucleotide Excision

Repair

Modulation of Therapeutic Sensitivity by HPV

Increased

G2 Cell Cycle

Arrest

Upregulation

of p53

Increased Immune

Cell Infiltration

Gilbert DC, Br J Cancer 2016; Dok R, Cancer Res 2014; Arenz A, Strahlenther Onkol 2014: Rieckmann T,

Radiother Oncol 2013; Kimple RJ, Cancer Res 2013; Gupta AK, Int J Radiat Oncol Biol Phys 2009.