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Automated planning – lexicographic multi‐criterial optimization (iCycle) 

Breedveld S, Storchi PR, Voet PW, Heijmen BJ. iCycle: Integrated, multicriterial beam angle, 

and profile optimization for generation of coplanar and noncoplanar IMRT plans. Med Phys. 

2012 Feb;39(2):951‐63.  

Breedveld S, Storchi PR, Heijmen BJ. The equivalence of multi‐criteria methods for 

radiotherapy plan optimization. Phys Med Biol. 2009 Dec 7;54(23):7199‐209.  

Breedveld S, Storchi PR, Keijzer M, Heemink AW, Heijmen BJ. A novel approach  

to multi‐criteria inverse planning for IMRT. Phys Med Biol. 2007 Oct 21;52(20):6339‐53. 

Voet PW, Dirkx ML, Breedveld S, Fransen D, Levendag PC, Heijmen BJ. Toward fully 

automated multicriterial plan generation: a prospective clinical study. Int J Radiat Oncol Biol 

Phys. 2013 Mar 1;85(3):866‐72. 

Voet PW, Breedveld S, Dirkx ML, Levendag PC, Heijmen BJ. Integrated multicriterial 

optimization of beam angles and intensity profiles for coplanar and noncoplanar head and 

neck IMRT and implications for VMAT. Med Phys. 2012 Aug;39(8):4858‐65. 

Voet PW, Dirkx ML, Breedveld S, Al‐Mamgani A, Incrocci L, Heijmen BJ. Fully automated 

volumetric modulated arc therapy plan generation for prostate cancer patients. Int J Radiat 

Oncol Biol Phys. 2014 Apr 1;88(5):1175‐9.  

Voet PW, Dirkx ML, Breedveld S, Heijmen BJ. Automated generation of IMRT treatment 

plans for prostate cancer patients with metal hip prostheses: comparison of different 

planning strategies. Med Phys. 2013 Jul;40(7):071704. 

Sharfo AW, Voet PW, Breedveld S, Mens JW, Hoogeman MS, Heijmen BJ. Comparison of 

VMAT and IMRT strategies for cervical cancer patients using automated planning. Radiother 

Oncol. 2015;114(3):395‐401. 

Rossi L, Breedveld S, Heijmen BJ, Voet PW, Lanconelli N, Aluwini S. On the beam direction 

search space in computerized non‐coplanar beam angle optimization for IMRT‐prostate 

SBRT. Phys Med Biol. 2012;57(17):5441‐58. 

Rossi L, Breedveld S, Aluwini S, Heijmen B. Noncoplanar Beam Angle Class Solutions to 

replace Time‐Consuming Patient‐Specific Beam Angle Optimization in Robotic Prostate 

Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2015;92(4):762‐70.  

Leinders SM, Breedveld S, Méndez Romero A, Schaart D, Seppenwoolde Y, Heijmen BJ. 

Adaptive liver stereotactic body radiation therapy: automated daily plan reoptimization