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Microbeam therapy (MRT) and the bystander effect
• MRT has been shown to effectively treat
tumours in vivo but has a sparing effect
on normal tissues
• The mechanism underpinning MRT is not
yet understood; bystander signaling has
been implicated
• Not all cells are able to induce bystander
effect though rapidly dividing cells, i.e.
tumour cells, may be more susceptible to
bystander signals
• Conflicting reports as to why some cells
produce bystander signals and others
don’t; p53 status has been implicated