680-681 / 1152
Day 0 Day 7 Day 14
Control
18Gy
Reduced Growth and Viability of tumour spheroids following
microbeam Irradiation.
1
10
100
0
5
10
15
20
Survival [%]
Dose [Gy]
BB Survival
Predicted MB survival
BB survival
MB survival
•
A549 Spheroids treated with Microbeam or
Broadbeam Irradiation
•
Growth measured using Celigo
cytometer
•
Viability measured at 14 days post treatment
•
The predicted response of the spheroids to
microbeam irradiation was calculated based on
the assumption of no communication between
cells.
•
The actual viability following MB falls below
the predicted
•
Cell:cell communication plays a role in MB
response in 3D culture