Microsoft Word - 0_Florence_Masterclass_2017_Programme

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Modelling tumour response: a
long successful story
 Fit of Clinical Data on local
control/survival
 Models of fractionation (LQ)
 Population-based TCP models
 Incorporating repopulation, hypoxia,
functional imaging information…
 Incorporation of dose distribution
heterogeneity, Dose painting and
response’s models for resistant sub-
volumes…
 Models of tumour progression and
regression
 Models of secondary cancer induction
Dose (Gy)
20 40 60 80 100
TCP
&
NTCP
(%)
0
20
40
60
80
100 TCP
NTCP
Dpr
Therapeutic Ratio
For a given fraction size