Microsoft Word - 0_Florence_Masterclass_2017_Programme

894-895 / 1152

Modelling normal tissues response:
a long successful story
 Assessment and modeling of dose-volume effects
 Quantitative (organ-based) relationships
 NTCP models through DVH reduction (LKB, gEUD….)
 Mechanistic models
 Impact of fractionation (LQ-based and updates…)
 Milestones of Emami/Burman paper (1991) and QUANTEC
Supplement (2009)
 
n
i
n/1
i i D*v EUD 





 
EUD
n ≈ volume effect
Veff
Vwhole
Dmax