896-897 / 1152
Modelling normal tissues response:
a long successful story
Assessment and modeling of dose-volume effects
Quantitative (organ-based) relationships
NTCP models through DVH reduction (LKB, gEUD….)
Impact of fractionation (LQ-based and updates…)
Milestones of Emami/Burman paper (1991) and
QUANTEC Supplement (2009)
n
i
n/1
i
i
D*v
EUD
EUD
n ≈ volume effect
V
eff
V
whole
D
max
Quantitative analyses dealing with the relationship
between dosimetric data (for instance DVH) and
toxicities are heavily present in our Journals and
their scientific impact is high…..!
Considering all papers published in the last 10 years
in the Green or Red Journal (n=10.500), 3/20, 8/50
and 12/100 most cited papers come from the field of
quantitative modelling of toxicity
………from ESTRO lecture: “How to bring QUANTEC into the 21° century ?» Turin 2016