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Esophageal cancer epidemiology

• 7th Leading cause of death

• Incidence in China 20-30 times higher than in USA

or Western Europe

• Age: peak in 6th to 7th decade

• Male/female incidence ratio = 3.5/1

• Squamous cell cancer and adenocarcinoma

represent 95% of cancers

SCC most common worldwide

Adenocarcinoma

Shift to >50% in USA and Western Europe over last 3 decades

Obesity, reflux disease, Barretts’s esophagus