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Clinical problem

Dysphagia and weight loss

Submucosal spreading

Resectable M0

Pre-op radiochemo + surgery better than surgery (level I)

Surgery alone in selected patients

Unresectable M0 disease

Pre-op radiochemo + surgery

Radiochemo alone

Replacement of radiotherapy by concurrent

radiochemotherapy (level I) was the most important

progress in esophageal cancer over the last 3

decades