Particle Therapy 2017

Progress in photon therapy

Technological progress: 2D –> 3DCRT –> IMRT

Omitting extended field irradiation

Comparative case-studies (level III) IMRT vs 3DCRT

–

Better OS and LRC (p < 0.01) [1]

–

Decrease in cardiac-related deaths (p=0.04) [1]

–

Decrease in weight-loss and G3-toxicity (p =0.01) [2]

Registry-analysis IMRT (

n=313

) vs 3DCRT (

n=2240

)

–

No significance in EC- or pulmonary-related mortality [3]

–

Significant differences in overall mortality, cardiac-mortality

and other-cause mortality [3]

1. Lin SH, et al. Int J Radiat Oncol Biol Phys 2012;84:1078-1085.

2. Freilich J, et al. Dis Esophagus 2015;28:352-357.

3. Lin SH., et al. Cancer. 2016;122:917–928.