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Unique anatomical and biological challenges

• Anatomical

Upper

Trachea, large vessels, spinal cord

Lungs

Middle

Main bronchi, lungs, spinal cord

Heart (atria (left!))

Lower

Heart (ventricles (left!))

Lungs, liver, stomach, spinal cord,

• Biological: adenocarcinomas?

Respond worse to radiochemo than SCC

Role for C-ion therapy?