54 / 2605
Mitosis
Clonogenic
survival
DNA
damage
response
Cell cycles
Early cell death
Apoptosis, Necrosis
Normal cells:
lymphocytes,
spermatogonia, intestinal cells,
embryonal cells
Tumors
of haematopoetic origin
Mitotic
catastrophe
Late cell death
Apoptosis, Necrosis
Vast majority of
proliferating
normal cells
Most tumor cells
Adopted from Wouters 2009
When and why cells die after irradiation ?
Multiple cell cycles
senescence
= cells cease to divide