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Exposed ends of the DNA strands
are detected by the
KU70–KU80
heterodimer
DNA-dependent protein
kinase (
DNA-PKcs
) stabilize
broken ends
The heterodimer
XRCC4/Ligase IV
subsequently
assists in repairing the break
XRCC
Ku70 Ku70
Ku80
Ku80
DNA-PK
Ligase
DNA repair:
Non-homologeous endjoining (NHEJ)
Double Strand Break (DBS)
Fast repair, can be
error-prone !!!
Loss of complete
sequences of bases
possible