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ionizing radiation
activation of the
survival response
network
DNA repair
cell survival
cell death
DNA lesions
excessive damage,
irrepairable
amount and type of damage
that can be handled
transducer
signaling pathways
second messengers,
tyrosin phosphorylation
effectors
e.g. repairosomes
damage
recognition
sensors
ATM, ATR, SMG1
adapted from: Shilof Y, Nature Reviews, 2003
Radiation damage registration & processing