48 / 2605
PARP
poly (ADP-ribosylation)
Ligase
XRCC
DNA-
pol
PARP
recognizes
both
single and double strand
breaks.
PARP causes poly (ADP-
ribosylation) to
enhance
access
to DNA single
strand repair proteins
such as XRCCI, Ligase III
and DNA polymerase .
DNA repair:
Non-homologeous endjoining (NHEJ)
Double Strand Break (DBS)