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Repopulation of clonogenic tumor cells
Surviving cancer cells proliferate during the intervals between treatments and this
process is an important cause of treatment failure.
Withers et al. Acta Oncol. 27: (1988)
TCD50 in head and neck tumors as
a function of overall treatment time
Bentzen and Thames 1991
When treatment time is extended beyond
about
1 month
, repopulation between dose fractions
increases the number of tumor cells that must
be killed.