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delay in the movement
of cells through
cell cycle phases
activation of
cell cycle
checkpoints !
Molecular Cell Biology
Lodish H, Berk A, Zipursky SL, et al. New York: ; 2000.
cell cycle
Radiation effects
mainly
normal
cells
late G2 checkpoint:
•
dose dependent
•
applies to cells
iradiated in G1 or S
•
affect radiosensitivity