590-591 / 2605
diffusion limited
irregular distribution of
tumor vessels lead to
limited O2 diffusion within
the tumor at distances
>100–200 µm.
Hypoxia in solid tumors
duration:
days to weeks
chronically
hypoxic cells
aerobic
cells
functional
blood
vessel
necrotic cells
perfusion limited
changes in vascular stability
+ dynamic fluctuations in
micro-regional tumor
perfusion within tortuous
blood vessels.
further affected by the
surrounding interstitial fluid
pressure
acutely
hypoxic
cells
transiently
occluded
blood vessel
duration:
minutes to few hrs
Horsman & Overgaard 1992