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Reoxygenation
(treatment-induced)
tumor
cell
stress granule
dying
tumor
cell
immune
cells
NO
ROS
released HIF1α
reoxygenation injury
stabilization of HIF1α
Increases growth factor
levels,
promoting
endothelial cell survival,
angiogenesis and tumor cell
survival and proliferation
More tumor cells with higher
oxygenation status, yielding
a better tumor cell kill
during the next radiation
fractions
Modified from Dewhirst et al., Nature Reviews Cancer 2008