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Repopulation
Conventionally RT delivery:
repopulation evident
3 – 4 weeks after
initiation
For tumor cells, repopulation partly
counteracts
the cell
killing effect of RT
(potential doubling time of tumors !)
Repopulation essential for normal tissue recovery !
Hypofractionation
Hypofractionated RT delivery:
repopulation complete within
1 – 2 weeks
Negligible or no substantial role after
high dose SBRT !