Particle Therapy 2017

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Page Background

ionizing radiation

activation of the

survival response

network

stress response

cell cycle

regulation

DNA repair

cell survival

cell death

DNA lesions

excessive damage,

irrepairable

amount and type of damage

that can be handled

consequences

transducer

signaling pathways

second messengers,

tyrosin phosphorylation

effectors

e.g. repairosomes

damage

recognition

sensors

ATM, ATR, SMG1

adapted from: Shilof Y, Nature Reviews, 2003

activation of the

cell death pathway

Radiation damage registration & processing