Particle Therapy 2017

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Page Background

ionizing radiation

activation of the

survival response

network

activation of the

cell death pathway

cell cycle

regulation

stress response

DNA repair

cell survival

cell death

DNA lesions

excessive damage,

irrepairable

amount and type of damage

that can be handled

consequences

low fidelity

repair

genetic

instability

transducer

signaling pathways

second messengers,

tyrosin phosphorylation

effectors

e.g. repairosomes

damage

recognition

sensors

ATM, ATR, SMG1

adapted from: Shilof Y, Nature Reviews, 2003

Radiation damage registration & processing