Particle Therapy 2017

Radiation-induced signals transmitted through existing pathways:

No radiation-specific pathways

Signaling in both directions !

death receptor

Fas-R

TRAIL-R

apoptosis

repair

proliferation

growth factors

e.g. EGF

inflammation

immunity, survival

cytokines

e.g.TNF-

alpha

damage-inducible and

stress-related proteins

reactive oxygen

species (ROS)

cytokines for intercellular

signaling

(TNF α, interleukin 1, 8, TGF ß)

cell survival

adhesion

migration

NFkB

Radiation-induced cell communication