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Summary Hypofractionation
always associated with an escala/on in
physical dose
vascular damage prominent at doses
> 10 Gy leading to indirect cell death
evidence for stem cell inac/va/on and
differen/al immunological effects
most features of the 5 R’s of conven/nal
frac/ona/on are different !
due to its increased biological effec/veness high-
LET intensifies the bioeffects of hypofrac/ona/on