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1940: Canadian born Charles Huggins recognized the
androgen dependence of PCA
1966: nobel price for medecine: discoveries concerning
hormonal treatment of PCA
1997: Zietman: the combination of radiation with
orchiectomy for Shionogi tumors treated in vitro resulted in
significant increase in control
Now, several large national and international RCT’s
confirmed and quantified the therapeutic benefit of ADT in
combination with EBRT
Wolff FR et al: Eur J Cancer, 2015;51:2345-2367
ADT