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BUT ALSO:

-Results given in terms of biochemical control

( almost the rule); this biochemical

control depends on local control (expected to be related to dose), but also on

“distant” control ( this essentially for high-risk patients), with no ( or much less)

relation to local dose (?)

-The percentage of patients receiving

Androgen deprivation therapy

(ADT). Large

variations from one series to another may introduce a bias in biochemical control

in some instances.

-The

follow-up

, which may be inadequate in some series.

-The

narrow range in D90

in most of the modern series

-……………..