1001 / 1138
Recurrences : if operable
Concomittant post op RT-CT
GETTEC-GORTEC 99-01 phase III
130 patients (on 494 screened)
SALVAGE SURGERY : 39% N+, 29% + margins, 55% E+, neural….
RANDOMISATION : Follow up vs RT-CT (60Gy/11w 3D + CT type Vokes
)
Toxicity :
Acute : 30% Gr 3-4
At 2 years : 39% versus 10% Gr 3-4
5 toxic death (8%)
impact on LRC & DFS
No impact on OS
Janot et al. JCO 2008