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Recurrences : not operable !!!

Chemotherapy/targeted therapies

Response rate 10-35%

Median survival 5-9 months

CDDP,

Targeted therapy (EGFr, VEGF…)

Reirradiation +/- CT ???

New drugs

New irradiation techniques ?

3D

IMRT

STEREOTAXIE

Soulieres

et al JCO 2004

Vermorken

et al. 2008