1005 / 1138
n
Treatment
Toxicity
Median
OS
LRC/OS
2 ans
De Crevoisier
1998
169
66 Gy / OHurea-5FU
60 Gy/ CDDP-5FU-myto
13% acute
12% late
3% bleeding
10 m 11% / 21%
Kramer
2005
38
60 Gy /
CDDP-paclitaxel
16% acute
29% late
12,4 m 37% / 35%
Salama
2006
66
66-74 Gy /
3 agents de CT
13% late
5% bleeeding
11 m 36% / 11%
Lee
2007
69
60 Gy 70% IMRT
70% CT conco
4% neuro
15 m 19% / 12%
Langer
2007
99
60 Gy /
CDDP-paclitaxel
28% acutes, 9% DC
12,1 m
19% / 26%
Spencer
2008
81
60 Gy / OHurea-5FU
23% acutes
8,2 m NR / 16%
Sulman
2009
54
66 Gy 100% IMRT
66% CT conco
32%acute
25,2 m 58% / 54%