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How to set the Clinical tolerance limit (
TL
D
)?
•
Clinical tolerance limits or specifications should be based on
clinical experience.
•
Clinical experience can be summarized through statistical
analysis of the outcome of a particular treatment for a
particular tumor disease.
•
Examples:
•
Local tumor control as a function of dose.
•
Fraction of survivors after five years as a function of
dose.
•
At the same time, normal tissue complications must be
taken into account.