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PCNSL: pathology
(A) DLBCL involving the left parietal lobe and
basal ganglia exhibits marked mass effect,
subependymal spread, and invasion of the lateral
ventricle at relapse, upon progression
with HD-MTX and rituximab-based
chemotherapy. (B) DLBCL cells exhibiting an
angiotropic
growth pattern in a diagnostic
specimen of PCNSL (H&E stain) (C) Invasive
growth of DLBCL cells along the cerebral
vasculature in PCNSL (H&E). D)
High
expression of MYC
by DLBCL cells in a
diagnostic specimen of PCNSL, as demonstrated
by immunohistochemistry
Rubenstein et al. Blood 2013