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JD Brody,

J Clin Oncol 2010;28(28):4324-4332

In situ vaccination with a TLR9 agonist

induces systemic lymphoma response

15 patients with r/r iNHL

CpG + low-dose RT single site of disease

Response assessment at distant sites

Treatment induced CD8+ memory T cells and Treg expansion in some patients

Best response in Tregs non inducers