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Conclusions (1)

Anti -PD-1-pathway-blocking agents highly active in HL but more limited

efficacy in other lymphomas. Mechanistic insights are emerging in HL

Currently very large number of combination therapies involving anti-PD-

1/PD-L1 agents and conventional chemotherapies, targeted therapies, or

other immunotherapies are being studied

CAR-T cells look promising in relapsed and refractory DLBCL and other

lymphoid malignancies. Efficacy and validity of delivery require on-going

further international studies

Clinical trials outrunning new immunological scientific insights.