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2 4 h r s

7 2 h r

7 d a y s

2 4 h r s

7 2 h r

7 d a y s

2 4 h r s

7 2 h r

7 d a y s

2 4 h r s

7 2 h r

7 d a y s

0

5 0 0 0

1 0 0 0 0

1 5 0 0 0

2 0 0 0 0

2 5 0 0 0

A

B

A

B

N o n T re a te d

5 x 2 G y R T +

P D -1 m A b

*

**

P D -L 1 e x p re s s io n o n

C D 4 5 - tu m o u r c e lls

*

*

*

**

Does RT and anti-PD1 leads to generation of systemic anti-tumour

immune responses ?

Dovedi et Clin Cancer Res 2017