Slide 1

150 / 1631

A=irradiated, B=shielded
2 4 h r s7 2 h r7 d a y s2 4 h r s7 2 h r7 d a y s2 4 h r s7 2 h r7 d a y s2 4 h r s7 2 h r7 d a y s
0
5
1 0
1 5
F re q u e n c y o f C D 4
+
ce lls
a s a p e rc e n ta g e o f C D 4 5 +
A B A B
N o n T re a te d 5 x 2 G y R T +
 P D -1 m A b
*
*
2 4 h r s7 2 h r
7 d a y s2 4 h r s7 2 h r
7 d a y s2 4 h r s7 2 h r
7 d a y s2 4 h r s7 2 h r
7 d a y s
0
1 0
2 0
3 0
4 0
F re q u e n c y o f C D 8
+
ce lls
a s a p e rc e n ta g e o f C D 4 5 +
A B A B
N o n T re a te d 5 x 2 G y R T +
 P D -1 m A b
**
*
*
RT and anti-PD1 therapy results in changes in TIL population with
increase in CD8 T cells
CD8 CD4
• RT and αPD-1 mAb leads to reduction in CD8+ T-cells (but not CD4 + T-cells) infiltrating the tumor
(when compared to out-of field lesions at 24 hours).
• Reduction in CD8+ T-cells acute, by day 7 both the irradiated and out-of-field tumors had significantly
greater numbers of CD8+ T-cells