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Anthracycline-containing chemotherapy increased HF rate by a

factor of 2.83 (95%CI: 1.43-5.59) with no significant interaction

with mean left ventricular dose (p=0.09).

No dose-effect relationship for anthracycline dose

No interaction with general risk factors CVD

Heart failure after HL

(1st event)

91 cases and 278 controls nested in cohort of 2,617 Dutch five-year survivors

of HL treated between 1965 and 1995

Van Nimwegen et al., Blood 2017