Slide 1

Established definitions of when treatment required – is this

still the right approach ?

Patients with at least one of the following requiring

initiation of treatment:

–

Bulky disease (nodal or extranodal mass > 7cm)

–

B symptoms

–

Elevated serum LDH (> ULN) or



2-microglobulin (> 3mg/L)

–

Involvement of ≥ 3 nodal sites (each > 3 cm)

–

Symptomatic splenic enlargement, compressive syndrome,

pleural/peritoneal effusion