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Is there a role for adjuvant chemotherapy with ISRT in
localised FL ?
10y FFTF
All
72%
Stage
II 70%
Bulk
5cm 65%
Age > 60
64%
Series of randomized trials, small and -ve
BNLI study chlorambucil – ve but persistent improvement
MDACC phase II
Seymour JCO 2003
Better than historical controls
Better in high risk groups
Prospective Australian trial: IFRT +/- RCVP
Macmanus, Seymour : presented at Lugano 2017