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Advanced stage disease : Goals of therapy versus
toxicity / tolerability in Follicular Lymphoma
•
Advanced FL generally considered incurable - most patients will require
additional therapy in their lifetime.
•
First line treatment options trade off between remission duration versus
toxicity. Eg R-CHOP induces more durable remissions relative to R-CVP
but carries more short-term toxicity and more risk for late cardiotoxicity
•
In absence of proven OS advantage for one choice versus another, no one
‘‘right’’ approach.
•
Treatment decision is patient-specific, incorporating goals of treatment with
the patient’s unique situation
–
Age, comorbidities, tumor burden, patient preferences.