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ESTRO 36 2017
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related hypertension, 0.60 (0.38-0.95) for preeclampsia,
and 0.62 (0.46-0.85) for gestational diabetes.
Conclusion
For female cancer patients received radiotherapy, the risk
of severe postpartum hemorrhage might be increased.
EP-1423 the evaluation of sleep quality in cancer
patients following the diagnosis of a metastatic site
E. Yirmibesoglu Erkal
1
, D. Celik
1
, S. Ozmen
1
, G. Aksu
1
,
H.S. Erkal
2
1
Kocaeli University, Department of Radiation Oncology,
Kocaeli, Turkey
2
Sakarya University, Department of Radiation Oncology,
Sakarya, Turkey
Purpose or Objective
The aim of this study was the evaluate the sleep quality in
cancer patients receiving palliative radiotherapy for the
first time following the diagnosis of a metastatic site and
to correlate the sleep quality with the depression status
and the level of hopelessness.
Material and Methods
Forty-eight metastatic cancer patients about to receive
palliative radiotherapy were evaluated using
questionnaires for Pittsburgh Sleep Quality Index (PSQI),
Beck Depression Inventory (BDI) and Beck Hopelessness
Scale (BHS). There were 12 females and 36 males, their
ages ranging from 27 to 77 years (median, 60 years). 39
patients were married and 14 patients had at least high
school education. Primary tumor site was listed as the
respiratory system in 14 patients and the genitourinary
system in 14. The time from the diagnosis of cancer to the
diagnosis of the metastatic site was less than 1 month in
17 patients, 1 to 6 months in 10 and over 6 months in 21.
Radiotherapy was delivered for bone metastases in 34
patients and brain metastases in 9.
Results
PSQI scores ranged from 0 to 17 (median, 10) and those
with scores over 8 were classified as poor sleepers. BDI
scores ranged from 0 to 36 (median, 15) and those with
scores over 10 were classified as having mild to severe
depression. BHS scores ranged from 0 to 16 (median, 4)
and those with scores less than 4 were classified as having
no hopelessness at all. Accordingly, there were 30 patients
who were poor sleepers, 29 who had mild to severe
depression and 25 who were hopeless. There was a strong,
positive correlation between PSQI scores and BDI scores
which was statistically significant (p=0.002). There was no
correlation between PSQI scores and BHS scores. There
was a statistically significant association between poor
sleep quality and single marital status (p=0.04).
Conclusion
Self-administered measurements such as PSQI, BDI and
BHS might be used as a simple means to collect data on
multiple facets of the sleep quality, the depression status
and the level of hopelessness. In this study, poor sleepers
were prevalent among metastatic cancer patients. Poor
sleep, associated with mild to severe depression, deserves
adequate medical attention in terms of supportive care
EP-1424 Fertility preserving high precision
radiotherapy in non-uterine pelvic malignancies in
female
P.S. Sridhar
1
, N. Madhusudhan
1
, K. Roopesh
1
, J. Vijay
kumar
1
, M. Praveen kumar
1
, A. Jerrin
1
, A. Pichandi
1
, B.
Ajai kumar
1
1
Health Care Global Enterprises Ltd, Cyberknife-
Radiation oncology, Bangalore, India
Purpose or Objective
Fertility is major issue in non-uterine pelvic malignancies
in reproductive age requiring radiation. Primary pathology
is most crucial. Malignancies which are potentially curable
will always have concern for quality of life and fertility
issues. High precision radiotherapy will be able to meet
both ends. In this retrospective study attempt had made
to reduce the dose to reproductive organs to preserve the
reproductive functions.
Material and Methods
5 cases of non-uterine malignancies of age between 9-30
years who were treated between 2009-2014 were
retrospectively analysed.2 were sacral tumors,1 STS of
pelvis,1 Ca rectum,1 RMS pelvis. All of them had one or
combination of surgery,chemotherapy.All of them were
required radiation, 4 of them were treated with Intensity
modulated radiotherapy and 1 with cyberknife.
Age
at
diagn
osis
Diagn
osis
Treatme
nt
Dose
to
prima
ry
Me
an
Dos
e to
ute
rus
Mean
Dose to
ovary
Reprod
uctive
functio
n
foll
ow
up
9
RMS
pelvi
s
Chemoth
erapy,
Bladder
preservin
g surgery
50Gy/
25Fr
IMRT
25G
y
9Gy/12
Gy
Menstru
ating
6
year
s 6
mon
ths
16
STS
sacru
m
surgery,
chemoth
erapy
66Gy/
33Fr
IMRT
28G
y
7.7Gy/
46Gy
Not
Menstru
ating
6
year
s 4
mon
ths
28
STS
sacru
m
Surgery 2
times
60Gy/
30Fr
IMRT
28G
y
7Gy/10
Gy
Deliver
ed baby
5
year
s 4
mon
ths
25
Ca
rectu
m
Chemoth
erapy,
surgery
IMRT
60Gy/
28Fr
28G
y
12Gy/9
Gy
Menstru
ating
3
year
s 8
mon
ths
26
STS
pelvi
s
Surgery,
Chemoth
erapy
30Gy/
5Fr
Cyber
knife
28G
y
3Gy/8
Gy
Menstru
ating
3
year
s 5
mon
ths
Results
Among 5 cases, all are alive, 4 pts (80%) have no disease 1
pt has recurred in postoperative area.4 (80%) patients are
having menstruation,1 had delivered healthy baby.1
patient having primary amenorrhoea is treated with
hormones.
Conclusion
High precision radiotherapy in non-uterine malignancies
will be able to deliver effective dose to the target, able
to achieve within tolerance dose to reproductive organs.
In highly selective subset of patients fertility preservation
can be attempted. However proper randomised trials in
this regard is warranted.
EP-1425 Permit to enter no-fly-zone: Risk-adapted
mediastinal SBRT for oligometastases safe and
effective
D. Holyoake
1
, R. Cooke
2
, K. Chu
2
, A. Buckle
2
, M. Hawkins
1
1
CRUK MRC Oxford Institute for Radiation Oncology,
Department of Oncology- University of Oxford, Oxford,
United Kingdom
2
Oxford University Hospitals NHS Foundation Trust,
Department of Clinical Oncology, Oxford, United
Kingdom
Purpose or Objective
Stereotactic Body Radiation Therapy (SBRT) to the central
chest & mediastinum must be undertaken with caution due
to the risks of severe toxicity that may be observed with
extreme hypofractionation schedules. A risk-adapted