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MRI-guided BT: GEC-ESTRO target definitions (2)
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HR CTV: whole cervix (assumed residual tumor)
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Persistent GTV
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Always whole cervix
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Presumed extracervical tumor extension:
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Residual clinically edematous zones
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Residual grey zones on MRI
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No safety margins are added
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Dose high enough to sterilize macroscopic tumor
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IR CTV: significant microscopic disease at BT
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Encompasses HR CTV
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Safety margins (5 – 15 mm) depending on tumor spread
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LR CTV: presumed treated with EBRT, not treated with BT
Haie-Meder C. et al. Radiother Oncol 2005.