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Meta-Analysis of Chemotherapy
in Head& Neck Cancer
MACH-NC
Platin-5FU: concomitant
vs
induction ?
Platin-5FU
Platin-5FU
Bourhis, Pignon 2009
EHNS-ESTRO H&N course
Florence, June 2016
Up-date MACH-NC : summary
Benefit with concomitant CDDP:
11% at 5
years
Higher benefit with concomitant CH:
confirmed (8%)
Small benefit of CT on survival :
confirmed
Benefit of CT observed in
post-op, and with
definitive RT (conventional / hyperfractionated)
Meta-Analysis of Chemotherapy
in Head& Neck Cancer
MACH-NC
Bourhis, Pignon 2009
EHNS-ESTRO H&N course
Florence, June 2016