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Late Toxicity
Analysis of 230 patients receiving CRT in 3 studies (RTOG 91-11, 97-03, 9-14)
10%
12%
27%
13%
43%
0
10
20
30
40
50
Patients
(%)
Any severe
late toxicity
Feeding-tube
dependence
>2 yrs post-RT
Pharyngeal
dysfunction
Laryngeal
dysfunction
Death
Machtay M, et al. J Clin Oncol 2008; 26: 3582–3589
Acute adverse effects: Grade ≥3
p<0.05
ns
Patients (%)
p<0.01
Wendt TG, et al. J Clin Oncol 1998;16:1318–1324
0
10
20
30
40
50
60
Xerostomia
Nausea/emesis
Leukopenia
Dermatitis
Mucositis
RT alone (n=140)
CRT (n=130)
ns, not significant
CRT = CDDP + 5-FU + RT
Toxicity of concomitant CH-RxTh for HNSCC
EHNS-ESTRO H&N course
Florence, June 2016
CH-RxTh or altered fractionation or a mix in HNSCC ?
Bourhis et al. Lancet Oncol, 2012
Median FU: 5.2 y
GORTEC 9902: overall survival
EHNS-ESTRO H&N course
Florence, June 2016