1357 / 2351
5/30/16
12
Hazard ratio
0.5 0.6 0.8 1.0
2.0 3.0
Meta-analysis on induction
chemotherapy with TPF
Overall survival
Budach, R&O, 2016
EHNS-ESTRO H&N course
Florence, June 2016
Non-surgical treatments for locally-advanced
laryngeal cancers
•
Efficacy RT-CH > RT alone (meta-analysis)
•
Efficacy HF or AF > RT alone (meta-analysis)
•
Efficacy C225-RT > RT alone (1 study!)
•
Efficacy EGFR inh-RT-CH
≤
RT-CH (≥ 2 studies)
•
Efficacy Acc RT-CH ≈ RT-CH (2 studies)
•
Efficacy Ind CH + RT (responders) ≈ TL + RT (2 studies)
•
Efficacy Ind-CH (TPF) > Ind-CH (PF) (2 studies)
•
Efficacy Ind CH + RT-CH ≈ RT-CH (3 studies)
•
Early & late toxicity RT + … > RT (many studies)
EHNS-ESTRO H&N course
Florence, June 2016