1353 / 2351
5/30/16
8
Treatment compliance to CRT or RT-EGFR-inh.
1Bonner JA, et al. N Engl J Med 2006; 354: 567–578
2Huguenin P, et al. J Clin Oncol 2004; 22: 4665–4673
3Calais G, et al. J Natl Cancer Inst 1999; 91: 2081–2086
4Wendt TG, et al. J Clin Oncol 1998; 16: 1318–1324
CRT arms of studies comparing CRT vs RT alone
Cisplatin / 5-FU / FA4
46%
51%
71%
90%
0
20
40
60
80
100
Carboplatin / 5-FU3
Cisplatin2
Cetuximab1
Patients receiving all planned doses (%)
10
70
50
30
90
Weekly doses (median 8 doses)
2 cycles at weeks 1 and
5
3 cycles at weeks 1, 4,
and 7
3 cycles at weeks 1, 3,
and 6
2nd cycle
3rd cycle
3rd cycle
EHNS-ESTRO H&N course
Florence, June 2016
Forastiere, 2013
Chemotherapy: Induction or Concomitant?
EHNS-ESTRO H&N course
Florence, June 2016