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Induction chemotherapy revisited with TPF
TAX 324
30% reduction in
risk of death
TAX 323
27% reduction in
risk of death
TPF
PF
Survival Time (months)
50
Survival Probability (%)
0 6 12 18 24 30 36 42 48 54 60 66 72
0
10
20
30
40
60
70
80
90
100
TPF
PF
Survival Time (months)
0 6 12 18 24 30 36 42 48 54 60 66 72
Posner et al, NEJM 2007
Resectable/unresectable disease
Vermorken et al, NEJM 2007
Unresectable disease
EHNS-ESTRO H&N course
Florence, June 2016
TPF
PF
Overall Survival (%)
0
20
40
60
80
100
Time from randomisation (Years)
0
1
2
3
4
5
6
7
8
100
78.2
59.5
51.7
45
42.4
39.4
37.7
32.7
71.6
52.2
44.7
38.8
35
32.8
29
26.3
Absolute difference
at 5 years
± SD:
7.4
± 2.59
p = 0.0002
Meta-analysis on induction
chemotherapy with TPF
Bourhis, personal communication 2011
EHNS-ESTRO H&N course
Florence, June 2016